| 8/31/2017 | Kentucky Wesleyan (2-8) | 7 | at | Murray State | 67 | GMAC (D2) | ||
| 9/9/2017 | Central Arkansas (10-2) | 41 | at | Murray State | 13 | SLC | ||
| 9/16/2017 | Murray State | 21 | at | Missouri State (3-8) | 28 | at MVC | ||
| 9/23/2017 | Austin Peay (8-4,7-1) | 27 | at | Murray State | 7 | |||
| 9/30/2017 | Murray State | 10 | at | Louisville (8-5) | 55 | at ACC | ||
| 10/7/2017 | Murray State | 13 | at | Tennessee-Martin (6-5,4-4) | 10 | |||
| 10/14/2017 | Eastern Illinois (6-5,5-3) | 27 | at | Murray State | 24 | 2OT | ||
| 10/28/2017 | Eastern Kentucky (4-7,3-5) | 26 | at | Murray State | 13 | |||
| 11/4/2017 | Murray State | 23 | at | Jacksonville State (10-2,8-0) | 59 | |||
| 11/11/2017 | Tennessee Tech (1-10,1-7) | 21 | at | Murray State | 31 | |||
| 11/18/2017 | Murray State | 10 | at | SE Missouri State (3-8,3-5) | 21 |
| vs Murray State | vs Other Opponents | Murray State compared to OOs | |
| Record: | 8-3 | 53-61 | |
| Points Scored: | 29.27 | 24.39 | -4.88 |
| Points Allowed: | 21.09 | 26.32 | -5.23 |
| Margin: | 8.18 | -1.93 | -10.11 |
| Total Points: | 50.36 | 50.71 | -0.35 |